While human genetic research promises to deliver a range of health benefits to the population, genetic research that takes place in Indigenous communities has proven controversial. Indigenous peoples have raised concerns, including a lack of benefit to their communities, a diversion of attention and resources from non-genetic causes of health disparities and racism in health care, a reinforcement of “victim-blaming” approaches to health inequalities, and possible misuse of blood and tissue samples. Drawing on the international literature, this article reviews the (...) ethical issues relevant to genetic research in Indigenous populations and considers how some of these have been negotiated in a genomic research project currently under way in a remote Aboriginal community. We consider how the different levels of Indigenous research governance operating in Australia impacted on the research project and discuss whether specific guidelines for the conduct of genetic research in Aboriginal and Torres Strait Islander communities are warranted. (shrink)

Erratum to: Bioethical InquiryDOI 10.1007/s11673-012-9391-xLobna Rouhani, University of Melbourne, is a co-author of the article “Genetic Research and Aboriginal and Torres Strait Islander Australians” (2012, 419–432) that was published in the Journal of Bioethical Inquiry’s 9(4) symposium “Cases and Culture.” Her name was omitted from the publication and she should be credited as the third author of this article.

This paper presents two different kinds a priori entitlements and argues that both are necessary to account for scientific knowledge. On the one hand, there are formal a priori entitlements whose existence is grounded in conditions on concept possession. On the other hand, there are material a priori entitlements that an agent accrues in virtue of practical reasoning. The discussion aims to reconcile the strengths of Christopher Peacocke’s and Michael Friedman’s recent work on the a priori, while overcoming the weaknesses (...) of their respective proposals. (shrink)

In September 2008, 10 years after the untimely death of Pere Alberch (1954–1998), the 20th Altenberg Workshop in Theoretical Biology gathered a group of Pere’s students, col- laborators, and colleagues (Figure 1) to celebrate his contribu- tions to the origins of EvoDevo. Hosted by the Konrad Lorenz Institute for Evolution and Cognition Research (KLI) outside Vienna, the group met for two days of discussion. The meeting was organized in tandem with a congress held in May 2008 at the Cavanilles Institute (...) for Biodiversity and Evolutionary Biology (ICBiBE) in Valencia, Spain. The talks at the KLI were equal parts: nostalgic remembrance, excitement over new ways of thinking about old problems, and an unrepressed vitriol against the resurgence of reductionist thinking in EvoDevo. Here we highlight some of the key aspects of Pere’s life and work that informed and infused the talks. (shrink)

Along with potential benefits to healthcare delivery, machine learning healthcare applications raise a number of ethical concerns. Ethical evaluations of ML-HCAs will need to structure th...

Jean-Francois Lyotard is often considered to be the father of postmodernism. Here leading experts in the field of cultural and philosophical studies, including Barry Smart, John O' Neill and Victor J. Seidler, tackle many of the questions still being asked about this controversial figure.

Aesthetic value empiricism claims that the aesthetic value of an object is grounded in the value of a certain kind of experience of it. The most popular version of value empiricism, and a dominant view in contemporary philosophical aesthetics more generally, is aesthetic hedonism. Hedonism restricts the grounds of aesthetic value to the pleasure enjoyed in the right kind of experience. But hedonism does not enjoy any clear advantage over a more permissive alternative version of value empiricism. This alternative is (...) aesthetic liberalism. On this view, an object’s aesthetic value is fully grounded in any value—not just the hedonic value—of a correct and complete experience of its sensory features. To demonstrate the advantages of liberalism over hedonism, I apply both views to analyze the aesthetic value of the Spring Temple Buddha and Anselm Kiefer’s Seraphim. I detail four advantages of liberalism over hedonism, and I conclude by defending liberalism from two kinds of objection. (shrink)

Le mot «milieu» est précieux pour souligner que les installations humaines – l’architecture, la ville – tiennent compte de leur environnement, naturel ou bâti. Avant de configurer «un monde», l’art humain configure un lieu et même l’élit et le transfigure en le métamorphosant, faisant de milieux donnés des «lieux» habitables voire mémorables aux multiples formes de délimitations, d’échanges et de devenir. La notion de milieu habité est mise en perspective et pensée en termes de limites, passages, liens et métamorphoses.

In this article, the place and the nature of an ethical dialogue that develops within Christian healthcare institutions in Flanders, Belgium is examined. More specifically, the question is asked how Christian healthcare institutions should position themselves ethically in a context of a pluralistic society. The profile developed by Caritas Catholica Flanders must take seriously not only the external pluralistic context of our society and the internal pluralistic worldviews by personnel/employees and patients, but also the inherent inspiration of a Christian healthcare (...) institution. This article concludes with ten general orientations that could shape the ethical dialogue from a Christian inspiration in a pluralistic context. (shrink)

This edited collection of essays brings together the leading experts in the field of cultural and philosophical studies to tackle many of the questions still being asked about Jean Francois Lyotard. Contributors include Barry Smart, John O'Neill and Victor J. Seidler with subjects ranging from Lyotard's writings on justice and politics of difference, on feminism, youth, judaism as well as a chapter devoted to his early writings.

I offer an appreciation and critique of Ernst Fehr’s altruism research in experimental economics that challenges the "selfishness axiom" as an account of human behavior. I describe examples of Fehr’s experiments and their results and consider his conceptual terminology, particularly his "biological" definition of altruism and its counterintuitive implications. I also look at Fehr’s experiments from a methodological perspective and examine his explanations of subjects’ behavior. In closing, I look at Fehr’s neuroscientific work in experimental economics and question his adherence (...) to a subjective expected utility interpretation of subjects’ behavior. Key Words: altruism • Ernst Fehr • strong reciprocity • neuroeconomics • experimental economics. (shrink)

The paper is concerned with the existence and asymptotic character of the nonlinear boundary value problemdG/dt=F ¦ –¦dF/dt=gG =k 1,G=k 2 as ¦– ¦ o+ The discussion is related to the problem of particle-number fluctuations in the theory of cosmic radiation andG andF denote respectively the probability generating functions for the electron distribution in an electron-initiated and a photon-initiated shower.A solution of the system satisfying the boundary conditions is constructed so that specified limiting conditions are fulfilled.

Despite its proliferation in technology studies, the concept of “path dependence” has scarcely been applied to epistemology. In this essay, I investigate path dependence in the production of scientific knowledge, first, by considering Kuhn's scattered remarks that lend support to a path-dependence thesis (Section I) and second by developing and criticising Kuhn's embryonic account (Sections II and III). I examine a case from high-energy physics that brings the path-dependent nature of scientific knowledge to the fore and I pay attention to (...) two sources of path dependence—“theoretical” and “instrumental”. The latter source is particularly important in “big science”. I ask in Section IV whether path dependence in scientific knowledge can lead to circumstances like those in the technological field, in which a theory can come to dominate a scientific speciality even though it is inferior to alternatives. In Section V, I ask what implications my thesis has for science policy. (shrink)

In this paper we examine Fehr’s notions of “altruism”, “strong reciprocity” and “altruistic punishment” and query his ascription of altruism. We suggest that, pace Fehr, altruism cannot be defined behaviourally because the definition of altruism must refer to the motives of actors. We also advert to certain inconsistencies in Fehr’s usage of his terms and we question his explanation of altruism in terms of ‘social preferences’.

The lysosome serves as a site for delivery of materials targeted for removal from the eukaryotic cell. The mechanisms underlying the biogenesis of this organelle are currently the subject of renewed interest due to advances in our understanding of the protein sorting machinery. Genetic model systems such as yeast and Drosophila have been instrumental in identifying both protein and lipid components of this machinery. Importantly, many of these components, as well as the processes in which they are involved, are proving (...) conserved in mammals. Other recently identified components, however, appear to be unique to higher eukaryotes. BioEssays 23:333–343, 2001. Published 2001 John Wiley & Sons, Inc. (shrink)

Kit Fine and Gideon Rosen propose to define constitutive essence in terms of ground-theoretic notions and some form of consequential essence. But we think that the Fine–Rosen proposal is a mistake. On the Fine–Rosen proposal, constitutive essence ends up including properties that, on the central notion of essence, are necessary but not essential. This is because consequential essence is closed under logical consequence, and the ability of logical consequence to add properties to an object’s consequential essence outstrips the ability of (...) ground-theoretic notions, as used in the Fine–Rosen proposal, to take those properties out. The necessary-but-not-essential properties that, on the Fine–Rosen proposal, end up in constitutive essence include the sorts of necessary-but-not-essential properties that, others have noted, end up in consequential essence. (shrink)

Looking out the window, I see that it's raining outside. Do I know that it’s raining outside? According to proponents of the Entailment Thesis, I do. If I see that p, I know that p. In general, the Entailment Thesis is the thesis that if S perceives that p, S knows that p. But recently, some philosophers (McDowell 2002, Turri 2010, Pritchard 2011, 2012) have argued that the Entailment Thesis is false. On their view, we can see p and not (...) know that p. In this paper, I argue that their arguments are unsuccessful. (shrink)

In 1986, a debate - der Historikerstreit (the historians’ dispute) - erupted in the German public sphere. It involved a number of historians who attempted to ‘revise’ approaches to the study of the Holocaust. Their endeavours met with fierce opposition, most notably from Jürgen Habermas, who accused them of trying to endow Germany with a presentable political image by relativizing the Holocaust. This article examines the conduct of the debate, in particular the manner in which each side alleged of the (...) other that it was driven by political motives rather than wissenschaftliche interests. I consider the way in which Ernst Nolte tries to ‘understand’ the Holocaust, and discuss the difficulties of investigating the Holocaust in a wissenschaftlichen manner.1. (shrink)

Stretching across Europe, Asia and Africa for half a millennium bridging the end of the Middle Ages and the early twentieth century, the Ottoman Empire was one of the major forces that forged the modern world. The chapters in this book focus on four key themes: frontier fortifications, the administration of the frontier, frontier society and relations between rulers and ruled, and the economy of the frontier. Through snapshots of aspects of Ottoman frontier policies in such diverse times and places (...) as fifteenth-century Anatolia, seventeenth-century Hungary, nineteenth-century Iraq or twentieth-century Jordan, the book provides a richer picture than hitherto available of how this complex empire coped with the challenge of administering and defending disparate territories in an age of comparatively primitive communications. By way of introduction, this chapter seeks to provide an overview of these four themes in the history of Ottoman frontiers. (shrink)

Whilst natural scientists have forged close links with industry, economists—in their capacity as consultants—with private enterprise, and psychologists with the burgeoning market for counselling services, philosophers have shown little eagerness to “ply their trade” in any commercial form whatsoever. Indeed, the very juxtaposition of concepts like “philosophy,” “money,” and “the marketplace” may already have raised eyebrows or induced mocking smirks. The image of this unworldly species assuming a commercial role comparable in scope or nature to that of practitioners of other (...) disciplines is scarcely imaginable. Thus, the peculiar nature of philosophy—its “subject matter,” “method,” or “corpus of knowledge”—provides one reason for prima facie scepticism. The advent of philosophical counselling in both Europe and America during the last decade may well shake such scepticism. It is primarily with this development that the authors in this volume of Philosophy in the Contemporary World deal. (shrink)

States claim the right to choose who can come to their country. They put up barriers and expose migrants to deadly journeys. Those who survive are labelled ‘illegal’ and find themselves vulnerable and unrepresented. The international state system advantages the lucky few born in rich countries and locks others into poor and often repressive ones. In this book, Christopher Bertram skilfully weaves a lucid exposition of the debates in political philosophy with original insights to argue that migration controls must be (...) justifiable to everyone, including would-be and actual immigrants. Until justice prevails, states have no credible right to exclude and no-one is obliged to obey their immigration rules. Bertram’s analysis powerfully cuts through the fog of political rhetoric that obscures this controversial topic. It will be essential reading for anyone interested in the politics and ethics of migration. (shrink)

Accelerated changes to the planet have created novel spaces to re-imagine the boundaries and foci of environmental health research. Climate change, mass species extinction, ocean acidification, biogeochemical disturbance, and other emergent environmental issues have precipitated new population health perspectives, including, but not limited to, one health, ecohealth, and planetary health. These perspectives, while nuanced, all attempt to reconcile broad global challenges with localized health impacts by attending to the reciprocal relationships between the health of ecosystems, animals, and humans. While such (...) innovation is to be encouraged, we argue that a more comprehensive engagement with the ethics of these emerging fields of inquiry will add value in terms of the significance and impact of associated interventions. In this contribution, we highlight how the concept of spatial and temporal scale can be usefully deployed to shed light on a variety of ethical issues common to emerging environmental health perspectives, and that the potential of scalar analysis implicit to van Potter’s conceptualization of bioethics has yet to be fully appreciated. Specifically, we identify how scale interacts with key ethical issues that require consideration and clarification by one health, ecohealth, and planetary health researchers and practitioners to enhance the effectiveness of research and practice, including justice and governance. (shrink)

Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

Economic theories of democratic legitimacy have criticized deliberative accounts of democratic legitimacy on the grounds that they do not represent a practical possibility and that they create conditions that make actual democracies worse. It is not simply that they represent the wrong ideal. Rather, they are too idealistic – failing to show proper regard for the cognitive and moral limitations of persons and the depth of disagreement in democratic society. This article aims to show that the minimalist criterion of democratic (...) legitimacy is self-defeating and that even if there are minimal cognitive, moral, and social requirements for the possibility of practicable deliberative democracy, these limitations do not necessarily impose insuperable barriers for democratic deliberation as the normative basis of democratic legitimacy. Thus, the limiting facts do not dictate the structure of appropriate normative models of democracy in the way minimalists have supposed. (shrink)

We can often permissibly choose a worse self-interested option over a better altruistic alternative. For example, it is permissible to eat out rather than donate the money to feed five hungry children for a single meal. If we eat out, we do something permissibly partial toward ourselves. If we donate, we go beyond the call of moral duty and do something supererogatory. Such phenomena aren’t easy to explain, and they rule out otherwise promising moral theories. Incommensurability and Ruth Chang’s notion (...) of parity can explain certain small improvement puzzles, but they can’t explain permissible partiality and supererogation. On the other hand, Josh Gert’s distinction between justifying and requiring weight can explain all three phenomena: permissible partiality, supererogation, and the relevant small improvement puzzle. Indeed, this chapter provides a reason to endorse the justifying/requiring weight distinction by showing that it provides the only extant explanation of all three phenomena. (shrink)

In this article, we use a corporate social responsibility (CSR) framework to analyze the payday loan industry by critically examining its practices from an economic, legal, and ethical perspective. Payday loans are essentially a very high cost, unsecured, short‐term personal loan. Given the inherent nature of the product being offered, the industry appears on the face of it to be in a position to potentially exploit vulnerable consumers in pursuit of profits. With this concern in mind, our analysis investigates the (...) following three issues: Can the payday loan industry currently be considered to be acting in a socially responsible manner? If the industry cannot be considered to be socially responsible, should it be further regulated? If the industry should be further regulated, how should it be regulated? To address these issues, we first provide a brief historical overview of payday loans. Second, we describe the important characteristics of payday loans and how the industry operates. Third, we draw on various sources of evidence to demonstrate that the payday loan industry, while fulfilling its basic economic obligations, falls outside of both the legal and ethical domains of the Three Domain Model of CSR. Based on our analysis, our conclusion is that the payday loan industry requires additional government legal regulation, particularly with respect to allowable fees, and we conclude that there is a strong ethical case for banning payday loans altogether. (shrink)

Public arguments can be good or bad not only as a matter of logic, but also in the sense that speakers can do good or bad things with arguments. For example, hate speakers use public arguments to contribute to the subordination of their targets. But how can ordinary speakers acquire the authority to perform subordinating speech acts? This is the ‘Authority Problem’. This paper defends a solution inspired by McGowan’s (Australas J Philos 87:389–407, 2009) analysis of oppressive speech, including against (...) concerns raised by McGowan (Just words: On speech and hidden harm, Oxford University Press, Oxford, 2019) herself. A deflated kind of authority can be gained from the hate speaker’s standing in a norm-governed ‘activity of oppression’. We should be wary about engaging with such speakers in public argument. Even if we counter their arguments, we may still elevate their standing within that activity and so enable them to perform more pernicious speech acts than was previously possible. (shrink)